Dr. Fritz H. Bach, a physician and medical researcher who helped develop techniques to improve people’s chances of surviving organ and bone marrow transplants, died Sunday at his home in Manchester-by-the-Sea, Mass. He was 77.
Fritz Bach, Who Aided Transplant Survival, Dies at 77
By DOUGLAS MARTIN
Published: August 17, 2011
The cause was cardiac arrest, his son Peter said.
In a transplant, a major worry is that the body will reject the new organ. So the goal is to find as compatible a donor as possible. A kidney transplant between identical twins in 1954 had proved to work, but most people needing transplants do not have twins.
Dr. Bach’s seminal contribution was to develop a process for systematically mixing cells from the patient with cells from potential donors until a donor is found whose cells do not react adversely with those of the patient. The technique provides a measure of how compatible the tissues from the two bodies are likely to be. The more likely, the less the possibility of rejection.
Dr. Bach graduated from Harvard in 1955 with a degree in physical science. He studied medicine at Washington University in St. Louis and Harvard Medical School, from which he received an M.D. in 1960. He taught and did research at the University of Wisconsin, the University of Minnesota and the Columbia and Harvard medical schools. He published more than 800 scientific papers.
Dr. Bach was married twice, to Marilyn Lee Brenner and Jeanne Elizabeth Gose. Survivors include his six children, David, Peter, Wendy, Kathryn, Erika and Dana, all of whom have his last name; and four grandchildren.
In recent years, Dr. Bach was concerned with transplanting pig organs to humans as a way to alleviate a persistent shortage in organs to transplant. He worried that swine tissue could unleash new diseases in humans, and did scientific research on ways to stop this. He advised proceeding, but methodically, and involving the public — not just experts — in making decisions about literally mixing species.
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